Hepatocyte growth factor receptor (HGFR) as a potential lung cancer target
نویسندگان
چکیده
منابع مشابه
Hepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies
Since its discovery in the late 1980s 1,2, hepatocyte growth factor (HGF) has been under intense investigation for its role in cancer. Hepatocyte growth factor has been established as a mitogen that regulates cell growth and death, a motogen that stimulates cell motility, a morphogen that modulates cell morphology and tissue or organ regeneration, and an angiogenic factor that induces angiogene...
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INTRODUCTION Epidermal growth factor receptor (EGFR) is an attractive drug target in lung cancer, with several anti-EGFR antibodies and small-molecule inhibitors showing efficacy in lung cancer patients. Patients, however, may develop resistance to EGFR inhibitors. We demonstrated previously that hepatocyte growth factor (HGF) induced resistance to EGFR tyrosine kinase inhibitors in lung cancer...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2018
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.2018.32.1_supplement.531.20